補體因子h(complement factor h)是膀胱腫瘤抗原(bladder tumor antigen, bta)的具體成分,是由尿路上皮腫瘤細胞和巨噬細胞產(chǎn)生的,不是正常表皮細胞產(chǎn)生的。補體因子h的產(chǎn)生賦予體內(nèi)腫瘤細胞一種選擇性生長優(yōu)勢,讓細胞逃逸宿主免疫系統(tǒng)監(jiān)視,幫助腫瘤細胞逃脫人體內(nèi)在調(diào)控避免凋亡 。當尿液補體因子h水平較高時,提示尿路上皮腫瘤的發(fā)生。補體因子h可用于尿路上皮腫瘤的早期檢測和復發(fā)監(jiān)測。
生物功能:
補體因子h(傳統(tǒng)習慣簡稱為bta)在控制補體激活替代途徑的時候扮演關(guān)鍵的負反饋作用,這個替代補體途徑可以裂解外來細胞。bta結(jié)合補體因子c3b后,可以抑制膜攻擊復合物的形成,從而阻止細胞裂解。bta干擾補體級聯(lián)反應,以免細胞被補體裂解。bta的產(chǎn)生賦予體內(nèi)腫瘤細胞一種選擇性生長優(yōu)勢,讓細胞逃逸宿主免疫系統(tǒng)監(jiān)視 。
臨床應用:
1檢測尿液補體因子h(bta)水平可對尿路上皮腫瘤進行早期鑒別和復發(fā)監(jiān)測。
2聯(lián)合尿液補體因子h(bta)和尿細胞學檢查用于膀胱癌高危人群篩查。
艾美捷補體因子h抗體及相關(guān)熱門研究:
編號名稱規(guī)格
m099mouse c1q小鼠補體c1q蛋白
m113mouse c3小鼠補體c3蛋白
m114mouse c3b小鼠補體c3b蛋白
r099rat c1q大鼠補體c1q蛋白
r113rat c3大鼠補體c3蛋白
r114rat c3b大鼠補體c3b蛋白
r137rat factor h大鼠factor h補體因子
rb113rabbit c3兔補體c3蛋白
r237goat anti-rat factor h山羊抗大鼠因子h抗體1.0ml
b102gvb++ (with ca and mg)*250ml
b100gvb++ (with ca and mg)*1liter
b103gvb° (without ca and mg)*250ml
b101gvb° (without ca and mg)*1liter
b104gvbe (with edta)*250ml
b105gvbe (with edta)*1liter
b110sgvb++ (low ionic strength gvb++ w/ sucrose)*250ml
b111sgvb++ (low ionic strength gvb++ w/ sucrose)*1liter
b112vbs++ (with ca and mg)*250ml
b113vbs++ (with ca and mg)*1liter
b114vbso (without ca and mg)*250ml
b115vbso (without ca and mg)*1liter
b200ea (ab-sensitized sheep e)*5ml@5x108/ml
b201ea (ab-sensitized sheep e)*10ml@5x108/ml
b202ea (ab-sensitized sheep e)*20ml@5x108/ml
b210es (sheep e)*20ml@5x108/ml
b300er (rabbit e)*5ml@5x108/ml
b301er (rabbit e)*10ml@5x108/ml
b302er (rabbit e)*20ml@5x108/ml
b400zymosan10ml@1x109/ml
b106mgegta10ml@0.1m
b250mcar1.0ml
hemolysinhemolysin2.0ml